The Petsalaki Group uses data-driven and network-based approaches to understand the principles underpinning context-specific cell signalling. We are an interdisciplinary team using computational and experimental approaches and methods from machine learning and network modelling to CRISPR and phosphoproteomics.
For this project you will be joining a multi-partner exciting collaboration funded by Open Targets to identify combination targets for KRAS-mutant colorectal cancer and triple negative breast cancer. This partnership includes the Garnett Group and industry partners from GSK and Sanofi.
You will be working in collaboration with the team to analyse the largest genetic interaction dataset generated to date in human cell lines (75K pairs across 50 cell lines) in order to prioritise candidate target pairs for therapeutic applications, understand the mechanisms and principles underpinning these genetic interactions. Additionally you will have the opportunity to develop a predictive model of drug synergy that is also interpretable in terms of mechanism of action.
- Extensive experience in programming in R or Python
- In-depth understanding of statistics for analysing biological datasets
- Excellent ability to collaborate and communicate with people of diverse backgrounds
- Enthusiasm and interest in the aims of the project to identify combination targets to tackle cancers with unmet clinical need
You might also have
- Experience using network analyses, knowledge-graphs and/or modelling
- Experience in machine learning
Why join us
Do something meaningful
At EMBL-EBI you can apply your talent and passion to accelerate science and tackle some of humankind's greatest challenges. EMBL-EBI is a worldwide leader in the storage, analysis and dissemination of large biological datasets. We provide the global research community with access to publicly available databases and tools which are crucial for the advancement of healthcare, food security, and biodiversity.
Join a culture of innovation
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.
Enjoy lots of benefits:
- Financial incentives: Monthly family, child and non-resident allowances, annual salary review, pension scheme including 17% employer contribution, death benefit, long-term care, accident-at-work and unemployment insurances
- Flexible working arrangements
- Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover)
- Generous time off: 30 days annual leave per year, in addition to eight bank holidays
- Relocation package including installation grant (if required
- Campus life: Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
- Family benefits: On-site nursery, 10 days of child sick leave, generous parental leave, holiday clubs on campus and monthly family and child allowances
- Benefits for non-UK residents: Visa exemption, education grant for private schooling, financial support to travel back to your home country every second year and a monthly non-resident allowance.
For more details please see our employee benefits page.
You can find out more about being a Postdoc at EMBL-EBI here.
What else you need to know
- Contract duration: 2 years with the possibility of an extension to include a 3rd year
- International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.
- Diversity and inclusion: At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ and individuals from all nationalities.
- Job location: This role is based in Hinxton, UK and you will be required to relocate once it is safe to do so, if you are currently based abroad. Read more about how we are recruiting during the pandemic.
- How to apply: To apply please submit a cover letter and a CV through our online system. We aim to provide a response within two weeks after the closing date - 16th May 2021.